First mention of the development of an eczematous reaction around melanocytic nevi dates back to 1971. At that time such reaction was regarded as an atypical pityriasis rosea with Koebner phenomenon around the nevi. Since then similar reaction, also called Meyerson’s phenomenon or halo eczema, has been described around various melanocytic (common acquired nevus, congenital nevus, dysplastic nevus, Spitz nevus, melanoma) and non-melanocytic (sebaceous nevus, seborrheic keratosis, dermatofibroma, nevus flammeus, basal cell carcinoma and squamous cell carcinoma) tumors. By now, different causes of Meyerson phenomenon have been proposed, including sunburns, atopic predisposition, chemotherapy and interferon-α treatment, but the exact reason of such reaction remains unknown.

Meyerson phenomenon typically occurs as a symmetrical erythema, vesiculation and scaling around one, some or all nevi of the patient. Lesions may be asymptomatic or pruritic and accompanied by eczema-like rash on healthy skin. More often Meyerson phenomenon occurs in males, locates on the trunk or proximal extremities. The eczematous reaction doesn’t modify the dermoscopic structures of the lesion, but can make them look blurred. Dermoscopic patterns mainly depend on type of the lesion around which Meyerson phenomenon occurs and are combined with typical features of eczema – dotted vessels, scales and yellow crusts. Histopathology reveals spongiosis, vesiculation and parakeratosis in the epidermis and superficial inflammatory infiltration in the dermis, associated with lymphocytic exocytosis.

For more information click here: http://scidoc.org/IJCDR-2332-2977-05-601.php

Dr. Boris NEDELCIUC,

Associate Professor, MD-PhD at Nicolae Testemitanu State University of Medicine and Pharmacy,

Chisinau, Republic of Moldova

Member of the Editorial Board of the International Journal of Clinical Dermatology & Research, USA

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