Weight-loss drugs will be offered to millions of people on the NHS, to help them manage their health.

One jab, Wegovy, is already available to some people and a second, Mounjaro, will soon be available – although it could be more than a decade before it is fully rolled-out.

NHS experts have warned that services are overstretched trying to deal with unprecedented demand from patients wanting to try weight-loss drugs.

How do Wegovy and Mounjaro work?

There are two drugs on the market – semaglutide, marketed under the brand name Wegovy, and tirzepatide, sold as Mounjaro. Semaglutide is also used in the diabetes treatment Ozempic.

Both Wegovy and Mounjaro are given as weekly injections via pre-filled pens that can be self-administered into the upper arm, thigh or stomach.

They work as an appetite suppressant by mimicking a hormone called glucagon-like peptide-1 (GLP-1).

This intestinal hormone is released after eating, and typically makes people feel fuller.

Mounjaro also affects another hormone, glucose-dependent insulinotropic polypeptide (GIP), which affects metabolism and helps regulate energy balance.

Patients generally start on a low dose which is gradually increased until they reach a higher maintenance dose.

How much weight do people lose?

People taking these drugs typically start to lose weight within a few weeks.

Clinical trials suggest that – when combined with changes to their diet, exercise and behavioural support – Wegovy users could lose more than 10% of their body weight after a year on the treatment.

Other trials suggest Mounjaro users might lose even more. But it is difficult to compare the two treatments and, crucially, users of either can put weight back on once they stop treatment.

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